Highlights from EBMT 2024: treating & managing GvHD & understanding the role of the gut microbiome
Apr 26, 2024
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Experts Mohamad Mohty, Ernst Holler, and Florent Malard share insights on treating GvHD post stem cell transplant, discussing new therapies and the impact of the gut microbiome. Topics include novel agents like ruxolitinib, the role of antibiotics on gut health, benefits of FMT in refractory disorders, and the link between bacterial antigens and transplant outcomes.
Ruxolitinib has emerged as a standard of care for acute GvHD, with promising results in steroid-refractory cases.
Manipulating the gut microbiome through fecal microbiome transplantation can improve outcomes in GvHD by restoring microbiota balance.
Deep dives
The Treatment of Acute GVHD: Focus on Ruxolitinib and Microbiome Modulation
The podcast episode highlights the challenges in treating acute graft versus host disease (GVHD) after allogeneic stem cell transplantation. It discusses the limited options in steroid-refractory cases, emphasizing the emergence of ruxolitinib as a standard of care. Additionally, it introduces promising results from microbiota modulation therapies, specifically highlighting the effectiveness of fecal microbiome therapy with the agent MAT13 in patients unresponsive to ruxolitinib, showing significant overall response rates and improved patient outcomes.
Advancements in Chronic GVHD Treatment: Ruxolitinib and Belumosudil
The episode delves into the treatment landscape of chronic graft versus host disease (GVHD) and the significant impact on patient quality of life. It showcases the efficacy of ruxolitinib and a ROC2 inhibitor, Belumosudil, in heavily pre-treated patients with advanced chronic GVHD, achieving high response rates across different manifestations of the disease. The discussion underscores the positive shift in managing chronic GVHD, aiming to enhance patient survival and well-being.
The Gut Microbiome's Influence on GVHD Severity and Treatment Strategies
The podcast presents insights into the critical role of the gut microbiome in graft versus host disease (GVHD) severity and treatment outcomes. It explores the impact of broad-spectrum antibiotics on microbiota diversity and subsequent dysbiosis, leading to GVHD complications. The episode discusses strategies like antibiotic stewardship and fecal microbiome transplantation to restore microbiota balance and improve patient prognosis. It also addresses the complex interactions between microbial strains, immune cells, and tissue antigens, highlighting the need for personalized approaches to combat GVHD.
Graft-versus-host disease (GvHD) is a common complication following allogeneic stem cell transplantation (alloSCT), which is typically classified as acute or chronic. In this week’s VJHemOnc podcast, we’ll be sharing key highlights from the 50th Annual Meeting of the EBMT, drawing focus on the biology and treatment of GvHD.
Tune in as experts Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, Ernst Holler, MD, University Hospital Regensburg, Regensburg, Germany, and Florent Malard, MD, PhD, Saint-Antoine Hospital and Sorbonne University, Paris, France, provide insights into current and emerging treatment approaches for acute and chronic GvHD, discussing the advent of new therapies. Following this, you’ll learn about the importance of the gut microbiome in the severity of GvHD and how this can be manipulated to improve patient outcomes.