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VJHemOnc Podcast

Highlights from EBMT 2024: treating & managing GvHD & understanding the role of the gut microbiome

Apr 26, 2024
Experts Mohamad Mohty, Ernst Holler, and Florent Malard share insights on treating GvHD post stem cell transplant, discussing new therapies and the impact of the gut microbiome. Topics include novel agents like ruxolitinib, the role of antibiotics on gut health, benefits of FMT in refractory disorders, and the link between bacterial antigens and transplant outcomes.
22:51

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Quick takeaways

  • Ruxolitinib has emerged as a standard of care for acute GvHD, with promising results in steroid-refractory cases.
  • Manipulating the gut microbiome through fecal microbiome transplantation can improve outcomes in GvHD by restoring microbiota balance.

Deep dives

The Treatment of Acute GVHD: Focus on Ruxolitinib and Microbiome Modulation

The podcast episode highlights the challenges in treating acute graft versus host disease (GVHD) after allogeneic stem cell transplantation. It discusses the limited options in steroid-refractory cases, emphasizing the emergence of ruxolitinib as a standard of care. Additionally, it introduces promising results from microbiota modulation therapies, specifically highlighting the effectiveness of fecal microbiome therapy with the agent MAT13 in patients unresponsive to ruxolitinib, showing significant overall response rates and improved patient outcomes.

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