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VJHemOnc Podcast

The future of CAR-T therapy in lymphoma, addressing the risk of secondary malignancy & the optimal sequencing of these agents with bispecific antibodies

May 16, 2024
Dr. Anna Sureda, an expert in CAR-T therapy, discusses the future of CAR-T therapy in lymphoma and the risk of secondary malignancies. Dr. Manali Kamdar provides an overview of CAR-T products and bispecific antibodies in large B-cell lymphoma, focusing on optimal sequencing for these agents to enhance efficacy.
12:34

Episode guests

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Quick takeaways

  • CAR-T therapy shows promise as a first-line treatment for high-risk non-hodgkin lymphoma patients, emphasizing improving efficacy and reducing toxicity.
  • Monitoring and surveillance are vital to understand and address the risk of secondary malignancies associated with CAR-T therapy in lymphoma patients, necessitating ongoing research efforts.

Deep dives

Future of CAR-T Therapy in Non-Hodgkin Lymphoma

CAR-T therapy is anticipated to play a significant role in the treatment of various subtypes of non-hodgkin lymphoma, with ongoing research focusing on utilizing CAR-T as first-line treatment strategies for specific high-risk patient groups. Emphasis is placed on improving CAR-T efficacy, reducing manufacturing time, and minimizing toxicity through translational and clinical research efforts.

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