The future of CAR-T therapy in lymphoma, addressing the risk of secondary malignancy & the optimal sequencing of these agents with bispecific antibodies
May 16, 2024
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Dr. Anna Sureda, an expert in CAR-T therapy, discusses the future of CAR-T therapy in lymphoma and the risk of secondary malignancies. Dr. Manali Kamdar provides an overview of CAR-T products and bispecific antibodies in large B-cell lymphoma, focusing on optimal sequencing for these agents to enhance efficacy.
CAR-T therapy shows promise as a first-line treatment for high-risk non-hodgkin lymphoma patients, emphasizing improving efficacy and reducing toxicity.
Monitoring and surveillance are vital to understand and address the risk of secondary malignancies associated with CAR-T therapy in lymphoma patients, necessitating ongoing research efforts.
Deep dives
Future of CAR-T Therapy in Non-Hodgkin Lymphoma
CAR-T therapy is anticipated to play a significant role in the treatment of various subtypes of non-hodgkin lymphoma, with ongoing research focusing on utilizing CAR-T as first-line treatment strategies for specific high-risk patient groups. Emphasis is placed on improving CAR-T efficacy, reducing manufacturing time, and minimizing toxicity through translational and clinical research efforts.
Secondary Malignancies and CAR-T Treatment
There is a growing concern regarding the development of secondary malignancies in patients receiving CAR-T therapy for lymphoma. While attributing these malignancies solely to CAR-T treatment is complex and challenging, long-term monitoring and surveillance are crucial to understanding the potential risks associated with these therapies. Research is ongoing to analyze the incidence and impact of secondary malignancies in the context of CAR-T treatment.
Sequencing of CAR-T Therapy and Bi-Specific Antibodies in Large B Cell Lymphoma Treatment
The approval of CAR-T products and bi-specific antibodies has transformed the landscape of large B cell lymphoma treatment, offering options for patients in different treatment settings. The optimal sequencing of CAR-T and bi-specific antibody therapies depends on various factors such as patient characteristics, treatment history, and response rates. While CAR-T therapy has demonstrated curative potential in the third-line setting, the use of bi-specific T cell engages is also expanding, with considerations for antigen expression and treatment efficacy.
Immunotherapeutic approaches, including CAR T-cells and bispecific antibodies, have become well-established in later lines of non-Hodgkin lymphoma (NHL) treatment. CAR T-cells are engineered to target specific antigens expressed on lymphoma cells, and bispecific antibodies simultaneously bind to both tumor cells and immune cells, enhancing the immune response against NHL.
This podcast features experts Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, who discusses the future of CAR-T therapy and the risk of secondary malignancies, and Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, who gives an overview of the currently approved CAR-T products and bispecific antibodies in large B-cell lymphoma, and the optimal sequencing of these agents.