A dive into the genetic history of India, and the role of vitamin A in skin repair
Mar 7, 2024
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Exploring the genetic history of India through large genome sequencing, including interactions with Neanderthals. Discussion on the role of vitamin A in skin repair and stem cell plasticity, highlighting its impact on hair growth and wound healing.
Modern Indian genomes show unique Neanderthal DNA distribution, indicating adaptive advantages.
Vitamin A, specifically retinoic acid, plays a vital role in directing stem cells for tissue repair.
Deep dives
Insights into Ancient Migrations and Neanderthal Ancestry in India
Research reveals that Indian populations exhibit a unique distribution of Neanderthal DNA fragments, with about 90% of known Neanderthal genome reconstructable from modern-day Indian genomes. Unique Neanderthal genetic sequences specific to Indian populations suggest potential adaptive advantages, possibly related to fighting diseases. The study sheds light on ancient migrations in India and the diverse intermingling of populations in the region.
Uncovering Iranian Ancestry Origins and Interconnected Migration Patterns
Genomic studies in India unveil the ancestral origins contributing to the Indian population, highlighting three main sources: indigenous South Asian hunter-gatherer populations, Iranian farmers around 5000 to 3000 BCE, and Eurasian steppe herders known as Yomnaya herders. The research indicates intricate migration patterns and genetic admixtures shaping the genetic landscape of modern-day Indians.
Role of Vitamin A in Regulating Stem Cell Fate Switching for Tissue Regeneration
Stem cells play a crucial role in tissue repair by adjusting their function through lineage plasticity. Research on the influence of vitamin A, specifically retinoic acid, in resolving lineage plasticity reveals its significance in directing stem cells back to their original physiological identities. Understanding these mechanisms provides insights into wound healing, skin regeneration, and potential therapeutic applications for degenerative conditions.
What modern Indian genomes say about the region’s deep past, and how vitamin A influences stem cell plasticity
First up this week, Online News Editor Michael Price and host Sarah Crespi talk about a large genome sequencing project in India that reveals past migrations in the region and a unique intermixing with Neanderthals in ancient times.
Next on the show, producer Kevin McLean chats with Matthew Tierney, a postdoctoral fellow at Rockefeller University, about how vitamin A and stem cells work together to grow hair and heal wounds.
This week’s episode was produced with help from Podigy.