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The discussion highlights significant advancements in CAR T-cell therapy for treating non-Hodgkin lymphoma (NHL), with emphasis on the use of autologous cells like AxiCell and Liso-cel as second-line treatments. These therapies have shown improvements in event-free and overall survival, leading practitioners to prefer CAR T-cell administration over traditional chemotherapy for eligible patients. However, some patients with urgent medical needs may require chemotherapy, and there remains a role for autologous transplants for select individuals who do not respond adequately to CAR T-cell therapy. The evolving understanding of various CAR T options continues to offer hope for expanding effective treatments for a wider range of patients, even those in older age brackets.