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VJHemOnc Podcast

CAR T-cells and bispecific antibodies in the treatment of NHL: updates from iwNHL 2024

Oct 15, 2024
In this discussion, Stephen Schuster and Jason Westin from top cancer centers delve into the latest in CAR T-cell therapy for non-Hodgkin lymphoma. They explore the treatment landscape, strategies to manage toxicities, and the promise of allogeneic CAR-T products. Joining them, Stephen Ansell and Martin Hutchings share insights on the role of bispecific antibodies, comparing their efficacy against CAR T therapies. They also address unique challenges and exciting combinations with antibody-drug conjugates that could redefine treatment approaches.
20:31

Podcast summary created with Snipd AI

Quick takeaways

  • Recent advancements in CAR T-cell therapy are offering significant improvements in event-free and overall survival for NHL patients, presenting a shift towards utilization over traditional chemotherapy.
  • The podcast emphasizes the importance of managing toxicities in bispecific antibody therapies, particularly cytokine release syndrome, while exploring combination strategies to enhance efficacy and minimize risks.

Deep dives

Advancements in CAR T-cell Therapy for Lymphoma

The discussion highlights significant advancements in CAR T-cell therapy for treating non-Hodgkin lymphoma (NHL), with emphasis on the use of autologous cells like AxiCell and Liso-cel as second-line treatments. These therapies have shown improvements in event-free and overall survival, leading practitioners to prefer CAR T-cell administration over traditional chemotherapy for eligible patients. However, some patients with urgent medical needs may require chemotherapy, and there remains a role for autologous transplants for select individuals who do not respond adequately to CAR T-cell therapy. The evolving understanding of various CAR T options continues to offer hope for expanding effective treatments for a wider range of patients, even those in older age brackets.

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