ICU Primary PrepCast #Epi 92 - ICU Primary Snippet 35 - Remifentanyl Vs Fentanyl
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Sep 14, 2024 Dive into the fascinating world of analgesics as fentanyl and remifentanil are compared in intensive care settings. Uncover the unique pharmacokinetics of each opioid, including their absorption and metabolism. Learn about context sensitivity half-time, revealing how quickly these drugs clear from the system after stopping an infusion. This analysis has crucial implications for patient management, especially for those with liver and kidney issues.
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Remifentanil vs. Fentanyl in ICU
- Remifentanil and fentanyl differ in pharmacokinetics, impacting their use in ICU.
- Remifentanil has a shorter duration and context-sensitive half-time than fentanyl.
Context-Sensitive Half-Time
- Context-sensitive half-time is the time for drug concentration to decrease by 50% after stopping infusion.
- Remifentanil's is shorter and independent of infusion duration, unlike fentanyl's.