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The Stem Cell Podcast

Ep. 10: RPE and Macular Degeneration Featuring Dr. Sally Temple

Jan 14, 2014
Dr. Sally Temple, scientific director of the Neural Stem Cell Institute, is a trailblazer in neural stem cell research. She discusses her groundbreaking discovery of a novel stem cell in the eye that holds promise for treating macular degeneration, the leading cause of blindness. The conversation also delves into the emotional impact of losing vision versus hearing and highlights the challenges gender disparity poses within the scientific community. Finally, they touch on innovative techniques in RPE cell research and preparations for future clinical trials.
01:12:44

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Quick takeaways

  • Dr. Sally Temple's discovery of stem-like cells in the adult brain has paved the way for innovative therapies in regenerative medicine.
  • Research on RPE cells is crucial for developing effective treatments for macular degeneration, addressing both dry and wet forms of the disease.

Deep dives

Understanding Macular Degeneration and RPE

Macular degeneration is the leading cause of blindness in individuals over the age of 65, affecting approximately 10 million people in the United States alone. The disease impacts the retinal pigment epithelium (RPE), a critical layer of cells behind the retina that supports photoreceptor function. There are two forms of macular degeneration: dry and wet. The dry form is characterized by gradual RPE degeneration, while the wet form involves abnormal blood vessel growth that can lead to severe vision loss.

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