Heart Health & Diabetes: How Diet & Hypoxia Affects Metabolic Flexibility · Dr. Latt Mansor · #131

Dr. Latt Mansor is the new Research Lead of H.V.M.N, and we're proud to share his fascinating research and upcoming work with our listeners!

In Dr. Mansor's thesis study, he found that the diabetic heart retains metabolic flexibility to adapt to hypoxia. Hypoxia is a condition when the body lacks adequate oxygen. Since diabetic hearts are more prone to hypoxia, getting closer to understanding if it could adapt to it was an important finding.

For context, diabetes and hypoxia have opposing effects on metabolic substrates in the heart. Diabetes promotes fatty acid oxidation and suppresses glycolysis, whereas adaptation to hypoxia suppresses fatty acid oxidation and promotes glycolysis.

The key result of Dr. Mansor's paper was that diabetic hearts did indeed adapt to chronic hypoxia, by increasing glycolysis and decreasing fatty acid oxidation.

In addition, Geoff & Dr. Mansor discuss:

• The implications of the study that was awarded the 2019 Nobel Prize in Medicine, which discovered how cells sense and adapt to oxygen availability
• The complex relationship between diet, oxygen, and HIF (our oxygen-sensing pathway)
• The potential of ketones to improve metabolic inflexiblity

Dr. Mansor's study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713751

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