VJHemOnc Podcast

CAR-T therapies and bispecific antibodies in the treatment of high-risk multiple myeloma: updates from iwHRMM 2024

11 snips
Nov 12, 2024
Krina Patel, an expert in CAR T-cell therapies at MD Anderson Cancer Center, dives into the cutting-edge treatments for high-risk multiple myeloma. She discusses the latest clinical trial findings and how CAR-T therapies are tailored for specific high-risk subgroups. The conversation also touches on the potential of allogeneic CAR T-cell products. Additionally, there’s a focus on bispecific antibodies, with insights on resistance mechanisms and combination strategies that may enhance treatment efficacy. This is an enlightening listen for cancer care innovators!
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INSIGHT

Functional High-Risk Myeloma and CAR-T

  • Functionally high-risk myeloma patients relapse quickly after transplant, often not reaching later lines of therapy.
  • Trials show CAR-T cells can improve progression-free survival, offering more time off therapy.
INSIGHT

Identifying Functional High Risk

  • Functional high-risk myeloma represents 15-20% of patients, even with quadruplet therapy.
  • Minimal residual disease (MRD) negativity may predict functional high risk before relapse.
ADVICE

Pre-CAR-T Treatment for Specific Subgroups

  • Treat plasma cell leukemia and CNS disease before CAR-T cell therapy.
  • This improves cell manufacturing and reduces toxicity risks.
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