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VJHemOnc Podcast

CAR-T therapies and bispecific antibodies in the treatment of high-risk multiple myeloma: updates from iwHRMM 2024

Nov 12, 2024
Krina Patel, an expert in CAR T-cell therapies at MD Anderson Cancer Center, dives into the cutting-edge treatments for high-risk multiple myeloma. She discusses the latest clinical trial findings and how CAR-T therapies are tailored for specific high-risk subgroups. The conversation also touches on the potential of allogeneic CAR T-cell products. Additionally, there’s a focus on bispecific antibodies, with insights on resistance mechanisms and combination strategies that may enhance treatment efficacy. This is an enlightening listen for cancer care innovators!
24:59

Episode guests

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Quick takeaways

  • CAR-T therapies show promise in improving progression-free survival for high-risk multiple myeloma patients, especially with prior disease control.
  • Bispecific antibodies present potential advantages and require further randomized studies to effectively address resistance mechanisms in high-risk scenarios.

Deep dives

Insights on CAR-T Therapies for High-Risk Myeloma

The podcast discusses the application of CAR-T therapies in treating high-risk multiple myeloma, highlighting the importance of identifying functional high-risk patients. These patients often have a history of early relapse after treatments and can benefit from CAR-T therapy applied earlier in their treatment journey. Clinical trials like CARMA-2 and CAR-T2 have indicated that although there is no cure, the progression-free survival (PFS) rates and the ability to achieve a time off therapy are promising. It is suggested that using MRD (minimal residual disease) negativity as a benchmark might help in identifying patients who are at risk for rapid disease progression.

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