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The podcast discusses the application of CAR-T therapies in treating high-risk multiple myeloma, highlighting the importance of identifying functional high-risk patients. These patients often have a history of early relapse after treatments and can benefit from CAR-T therapy applied earlier in their treatment journey. Clinical trials like CARMA-2 and CAR-T2 have indicated that although there is no cure, the progression-free survival (PFS) rates and the ability to achieve a time off therapy are promising. It is suggested that using MRD (minimal residual disease) negativity as a benchmark might help in identifying patients who are at risk for rapid disease progression.