How to safely undergo IVF with von Willebrand disease

Renowned fertility specialist Oluyemisi (Yemi) Famuyiwa discusses her article, "When bleeding disorders meet IVF: Navigating von Willebrand disease in fertility treatment." She explains that von Willebrand disease (VWD), the most common inherited bleeding disorder, affects up to 1 percent of the population and poses unique challenges for women undergoing fertility treatments. Because many women normalize symptoms like heavy menstrual bleeding, VWD often goes undiagnosed until an invasive procedure like IVF egg retrieval reveals the condition. Yemi details the specific risks, including hemorrhage during oocyte retrieval, and outlines a comprehensive management strategy. She emphasizes that while IVF is feasible for women with VWD, it requires a carefully planned, multidisciplinary approach involving both hematologists and reproductive specialists. This includes a thorough pre-IVF workup to determine VWD type and severity, a personalized prophylaxis plan that may include desmopressin or factor replacement, and close monitoring during the procedure and postpartum period to ensure a safe and successful outcome.

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