Jan 10 2025 This Week in Cardiology

Jan 10, 2025

This week's discussion tackles the significant cancer risks associated with alcohol consumption, spotlighting a new advisory from the Surgeon General. The podcast also delves into the challenges of applying GLP-1 trial findings to real-world patient care due to rigorous exclusion criteria. Insights on stress testing reveal important nuances in diagnosing coronary artery disease. To wrap up, listeners learn about a positive trend: decreasing stroke rates in atrial fibrillation patients, highlighting advancements in treatment.

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Intro

00:00 • 2min

Understanding Bias in Alcohol Studies and Challenges with GLP-1 Applications

02:06 • 10min

Insights on Stress Testing and Ischemic Stroke Trends in Cardiology

11:43 • 19min

Alcohol and cancer, GLP-1 trial representativeness, diagnosing CAD, changing stroke rates in patients with AF, blanking periods after AF ablation are the topics John Mandrola, MD, covers this week.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Surgeon General Causes Hoopla Regarding ETOH Warning

Dry January: Should Doctors Make It Year-Round?

https://www.medscape.com/viewarticle/dry-january-should-doctors-make-it-year-round-2025a100009t

Surgeon General Warning https://www.hhs.gov/about/news/2025/01/03/us-surgeon-general-issues-new-advisory-link-alcohol-cancer-risk.html
GBD 2016 Collaboration Lancet https://doi.org/10.1016/S0140-6736(18)31310-2
RCT Voskobonik and colleagues https://www.nejm.org/doi/full/10.1056/NEJMoa1817591
Marcus and colleagues; UCSF https://pubmed.ncbi.nlm.nih.gov/33516710/
Review of ETOH AF https://doi.org/10.1016/j.jacc.2016.08.074

II. GLP-1 Agonists for Obesity –Trial vs Real World

Generalizability of Trial Results https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2826335
HRS Document ICD http://dx.doi.org/10.1016/j.hrthm.2014.03.041

III. Stress Testing and CAD Severity

Reynolds and colleagues. Observational ISCHEMIA Sub-analysis https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013743
Foy Meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243
ISCHEMIA https://www.nejm.org/doi/full/10.1056/NEJMoa1915922

IV. Changing Stroke Rates with AF

Teppo and colleagues. Finnish Study https://doi.org/10.1016/j.jacep.2024.10.029
Quinn and colleagues. https://www.ahajournals.org/doi/10.1161/circulationaha.116.024057

V. Patients’ Lives Don’t Pause for Blanking Periods

Ruzieh and colleagues. https://doi.org/10.1016/j.ahjo.2024.100497

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