ICU Primary PrepCast # Epi 76 - ICU Primary Snippet 19 - pK/pD changes at Term in Pregnancy
Jun 11, 2023
Exploring the impact of pregnancy on drug absorption, distribution, metabolism, and elimination, including changes in drug bioavailability, plasma volume, protein levels, hepatic enzyme activity, and glomerular filtration rate. The podcast also discusses pharmacodynamic alterations across multiple systems and considerations for administering drugs during pregnancy.
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Pharmacokinetic Changes in Pregnancy
- Pregnancy alters drug absorption, distribution, metabolism, and elimination.
- These changes necessitate careful consideration of drug choice and dosage.
Drug Absorption
- Gastric pH increases, affecting absorption of weak acids and bases.
- However, studies show oral bioavailability remains largely unchanged.
Drug Distribution and Placental Transfer
- Increased plasma volume affects hydrophilic drug distribution, while decreased albumin impacts protein-bound drugs.
- The placental barrier and fetal pH influence drug transfer and potential toxicity.