NEI Podcast cover image

NEI Podcast

E243 - A Look Back at This Year in Psychopharmacology with Dr. Roger McIntyre

Dec 4, 2024
Dr. Roger McIntyre, a leading mental health expert in psychopharmacology, joins Dr. Andy Cutler to reflect on significant advances in the field this year. They dive into groundbreaking treatments for schizophrenia, discussing innovative drugs and their potential in improving cognitive and negative symptoms. The conversation also covers the complexities of prescribing anticholinergic medications and advancements in TMS therapy for adolescent depression. Insights on suicidality, mood disorders, and the interplay between sleep and mental health leave listeners with a deeper understanding of these crucial topics.
01:05:46

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • The FDA approval of Kobenfi introduces a novel schizophrenia treatment that uniquely targets muscarinic acetylcholine receptors for better efficacy and tolerability.
  • The conversation highlights a shift towards the third wave of psychopharmacology, focusing on treatments that address multiple neurotransmitter systems beyond dopamine.

Deep dives

Introduction of Kobenfi as a Revolutionary Treatment

A significant development in psychopharmacology was marked by the FDA approval of Kobenfi, a novel drug with a unique mechanism for treating schizophrenia. This drug, a combination of xenomaline and trospium, represents a paradigm shift, moving away from the traditional antipsychotics that primarily blocked dopamine receptors. The new mechanism targets muscarinic acetylcholine receptors, offering a fresh approach that aims to reduce dopamine release rather than block its receptor sites. This innovative treatment is expected to bring improvements in both tolerability and efficacy for patients, especially those who experience severe side effects from classic medications.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode