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VJHemOnc Podcast

Post-ASH NHL highlights: novel combinations in the frontline setting and advancements with immunotherapy in the R/R setting

Jan 24, 2025
Catherine Diefenbach, MD, from NYU Langone, discusses cutting-edge advancements in non-Hodgkin lymphoma therapies. She highlights promising novel combinations for diffuse large B-cell lymphoma and mantle cell lymphoma, including a triplet regimen with acalabrutinib. The use of bispecific antibodies is also explored, showcasing their therapeutic potential. Diefenbach shares insights from the recent ASH meeting on CAR T-cell therapy advancements, emphasizing new treatments that enhance patient accessibility and response rates.
31:20

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Quick takeaways

  • Novel combinations in frontline settings, such as polituzumab with R-CHOP and venetoclax with RCHP, show significant response rates and survival benefits.
  • Advancements in CAR T-cell therapies, particularly AxiCell, demonstrate a high overall response rate in relapsed/refractory NHL, indicating curative potential.

Deep dives

Advancements in Treatment Approaches for Non-Hodgkin Lymphoma

Novel combinations of therapies are being explored for the treatment of non-Hodgkin lymphoma (NHL), particularly for previously untreated cases. The Polarix trial, which investigated the addition of polituzumab to the standard R-CHOP regimen, showed sustained progression-free survival benefits for patients over five years, particularly for those with high-risk disease subtypes. Additionally, combining venetoclax with the RCHP regimen demonstrated impressive response rates, particularly achieving a 100% response rate in challenging double and triple-hit lymphoma patients. These findings underscore the potential for precision medicine approaches in improving outcomes for NHL patients with biological complexities.

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