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The Drug Discovery World Podcast

DDW Highlights: 26 February 2024

Feb 26, 2024
FDA approves first cell therapy for solid tumors; Breakthrough in islet cell therapy for diabetes; FDA approval of AMTAGVY for melanoma; Advances in cell and gene therapy manufacturing; Collaboration in immuno-oncology therapeutics; Tau-targeting therapies for Alzheimer's disease
15:10

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Quick takeaways

  • Successful insulin independence achieved in non-human primate with HIP modified islet cells, potentially eliminating insulin injections.
  • FDA approves AMTAGVY cellular therapy for metastatic melanoma, demonstrating high objective response rate and durable responses.

Deep dives

Potential Revolutionary Treatment for Type 1 Diabetes

Preclinical data showcases insulin independence in a diabetic non-human primate post-transplantation of HIP modified islet cells, without immunosuppression. The study by SANA Biotechnologies reveals effective endocrine function of the modified islets, potentially eliminating the need for insulin injections. The research sets a high immunological benchmark by achieving insulin independence and maintaining stable glucose levels in the recipient without any immune reactions. Clinical trials are awaited to further validate the safety and effectiveness of this transformative approach.

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