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In this episode of "The Incubator" at NeoHeart 2024, hosts Ben and Daphna interview Dr. Sam Gentle, a neonatologist presenting at the conference.

Dr. Gentle discusses his upcoming talk on the potential impact of patent ductus arteriosus (PDA) on the progression of bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension. He emphasizes the lack of pulmonary hypertension as an outcome in previous PDA trials and the importance of considering PDA as a continuous exposure rather than a binary one.

The conversation touches on the challenges of determining when to intervene in cases of prolonged PDA exposure. Dr. Gentle shares insights from his research, suggesting that PDA exposure beyond 2-3 months may significantly increase the risk of pulmonary hypertension in premature infants.

They discuss the cognitive biases that can affect clinical decision-making regarding PDA treatment and the need for statistical analysis to guide interventions. Dr. Gentle also mentions an upcoming trial on percutaneous PDA closure that will assess pulmonary hypertension as an outcome.

The episode highlights the ongoing debate in neonatology regarding PDA management, particularly the question of how long is too long to leave a PDA open. Dr. Gentle appreciates the conference's multidisciplinary approach, noting the value of gaining perspectives from cardiologists on these complex issues

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!