Core IM | Internal Medicine Podcast
#153 HFpEF: 5 Pearls Segment
Jun 5, 2024
Explore the complexities of HFpEF: causes, diastolic dysfunction, BNP levels, scoring systems, and treatment options. Learn about the challenges in diagnosis, risk scores, alternative maneuvers, and comprehensive management strategies. Delve into the nuances of HFpEF management with medications, gender differences, and research updates.
39:46
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Quick takeaways
- Diastolic dysfunction does not always indicate HEF PEF, highlighting the importance of a comprehensive diagnostic approach.
- Treatment for HEF PEF involves addressing risk factors, utilizing SGLT2 inhibitors as first-line therapy, and incorporating MRAs and ARNIs.
Deep dives
Understanding Heterogeneity in Heart Failure with Preserved Ejection Fraction (HEF PEF)
Heart failure with preserved ejection fraction (HEF PEF) is characterized by a nuanced understanding of its clinical syndrome, not simply attributed to known etiologies. The umbrella term of HEF PEF encompasses various conditions under a poorly understood systemic disorder. Rather than a clear diagnosis, it presents as a syndrome involving dyspnea due to rising left ventricular filling pressures. The complexity lies in factors like obesity, cardiovascular disease, and systemic inflammation impacting endothelial dysfunction and myocardial abnormalities.
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