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Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.

In this episode, we discuss:

(00:00) Introduction
(07:36) Defining cardiovascular disease
(09:43) Coronary plaque and fatality risk
(13:34) How ApoB predicts heart disease
(21:34) Factors elevating ApoB
(27:23) Does high ApoB cause cardiovascular disease
(37:01) ApoB thresholds for ASCVD prevention
(40:27) Dietary factors raising ApoB
(49:33) Genetics of ApoB and LDL
(53:24) Does low LDL increase cancer?
(56:19) Cholesterol-lowering drugs
(59:59) Statins, uses, and side effects
(1:03:12) Are statins toxic to mitochondria?
(1:09:56) Ubiquinol for statin-induced muscle soreness
(1:11:09) How to train in zone 2
(1:17:09) Statins and neurodegenerative disease risk
(1:21:54) Cholesterol synthesis in the brain (desmosterol role)
(1:25:58) Statin alternatives
(1:36:49) Berberine for CVD Risk Reduction?
(1:39:36) Muscle as a glucose sink
(1:51:38) Hemoglobin A1C Levels and Mortality Data
(1:55:35) 80/20 Zone 2/VO2 Max Training Protocol
(2:02:12) Insights from VO2 max testing data
(2:12:17) How obesity increases cancer risk
(2:15:03) Cancer screening
(2:40:32) Menopause – hormonal shifts and health effects
(2:45:13) Hormone replacement therapy (HRT)
(2:58:57) Perimenopause diagnosis with hormone levels
(3:02:04) HRT's impact on dementia, cancer, and heart disease risk
(3:07:42) Vitamin D
(3:16:24) Testosterone replacement for women's sexual function
(3:18:47) HRT safety 10 years post-menopause
(3:23:05) Testosterone & TRT
(3:32:33) Blood pressure
(3:45:30) Peter's longevity optimization routines

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(PREVIEW) Ep. 85: Why So Cynical? ft. David Sirota