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The Long Run with Luke Timmerman
Ep163: Sarah Boyce on RNA Medicines for Muscle Diseases
Aug 14, 2024
Sarah Boyce, CEO of Avidity Biosciences, shares her inspiring journey from Liverpool to leading a company focusing on RNA medicines for rare muscle diseases. She discusses the innovative therapies being developed for conditions like myotonic dystrophy and Duchenne muscular dystrophy. The conversation dives into the challenges of transitioning to a CEO role and the significance of emotional intelligence in leadership. Boyce also highlights advancements in RNA therapeutics, including promising drug trials and the importance of community engagement in biotechnology.
01:08:19
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Quick takeaways
- Avidity Biosciences is pioneering antibody oligonucleotide conjugates, transforming the treatment of rare muscle diseases through targeted RNA delivery.
- CEO Sarah Boyce emphasizes visionary leadership and community engagement as key components in bridging innovative science with patient access to therapies.
Deep dives
Innovative RNA Delivery Technology
The discussion centers around Avidity Biosciences’ development of antibody oligonucleotide conjugates, a groundbreaking approach to delivering RNA therapies directly to muscle cells. This technology enables the precise targeting of disease-related proteins in challenging conditions where traditional RNA medicines have struggled. Avidity has gathered extensive clinical trial data supporting its platform, particularly for conditions like myotonic dystrophy and facioscapulohumeral muscular dystrophy (FSHD). The delivery of RNA molecules to muscle indicates a significant advancement in treating rare muscle disorders previously considered untreatable.
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