Why is hemochromatosis so common? What is iron actually doing to the joint? Does phlebotomy help? What’s going on with iron and Popeye? These are the questions we tackle in the second episode of hemochromatosis: Iron and Bone!

Brought to you by GSK.

Intro :19
Today’s episode :29
Why is hemochromatosis so common? 1:06
The history of Popeye the Sailor Man 3:37
Treatment with phlebotomy 8:35
Why doesn’t join pain improve? 12:03
What is Kashin-Beck disease? 14:18
Mouse studies from the 1970s 19:45
What about histology? 25:36
Episode wrap-up 28:34

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Adams PC, et al. Hepatology. 1997;25:162-166.

Adams PC, et al. N Engl J Med. 2005;352:1769-1778.

Brighton CT, et al. Arthritis Rheum. 1970;13:849-857.

Heiland GR, et al. Ann Rheum Dis. 2010;69:1214-1219.

Hiyeda, K. Jap Med Sci. 1939;4:91-106.

Powell LW, et al. Lancet. 2016;388:706-716.

Rametta R, et al. Int J Mol Sci. 2020;21:3505.

Sella EJ, Goodman AH. J Bone Joint Surg Am. 1973;55:1077-1081.

Sutton M. Internet Journal of Criminology. 2010;1-34.

The Iron Fist, Part 2: Iron and Bone