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Hemolysis Paradox
- Rhabdomyolysis and hemolysis present a paradox regarding acute kidney injury (AKI).
- Though both involve heme, a toxic molecule, rhabdomyolysis causes AKI more readily.
Hemolysis and AKI
- Hemolysis can cause AKI, though less commonly than rhabdomyolysis.
- Historically, ABO mismatch was the primary cause, but contemporary causes are more varied.
Haptoglobin's Protective Role
- Access to renal tubules is crucial for pigment nephropathy.
- Haptoglobin binds free hemoglobin, forming complexes too large for kidney filtration, thus protecting against AKI.