The entrepreneur dreaming of a factory of unlimited organs
Sep 18, 2024
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Martine Rothblatt, a visionary entrepreneur with a background in satellite technology, discusses her ambitious quest to create unlimited transplantable organs, driven by her daughter’s health challenges. She reveals plans for a genetic farm to harvest modified pig organs, tackling the critical organ shortage crisis. The conversation delves into the revolutionary potential of xenotransplantation and 3D bioprinting while addressing the ethical dilemmas and regulatory hurdles that come with these groundbreaking advancements in organ transplantation.
Martine Rothblatt's vision for an unlimited supply of transplantable organs includes genetically modified pigs and advanced 3D printing technology to alleviate waiting lists.
Significant breakthroughs in xenotransplantation, such as successful pig organ transplants, showcase the potential to revolutionize organ availability for patients in need.
Deep dives
The Vision of Unlimited Transplantable Organs
Martine Rothblatt envisions a future where transplantable organs, including those 3D printed, are readily available, aimed at addressing the critical shortage faced by patients on transplant lists. With over 100,000 people waiting for transplants in the U.S. alone, the despair of those awaiting organs led Rothblatt to innovate solutions when her daughter was diagnosed with a fatal lung disease. Her proposal includes constructing an organ farm with genetically modified pigs producing compatible organs, signaling a shift towards utilizing animal organs as a viable transplant source. This ambitious project could potentially revolutionize organ availability, allowing many more patients to receive necessary transplants and ultimately saving lives that would otherwise be lost due to lack of suitable donors.
Progress in Xenotransplantation
Rothblatt’s work has already seen significant milestones in the field of xenotransplantation, particularly with the successful transplant of genetically engineered pig organs into human subjects. Notably, a pig kidney was connected to a brain-dead patient in 2021, marking a critical step in understanding organ compatibility and function in humans. More recently, a living patient received a pig heart, surviving for two months, demonstrating the potential for life-sustaining transplants beyond human donors. These pioneering procedures illustrate not only the feasibility of using animal organs but also the potential to alleviate the organ transplant crisis in a profound way.
Challenges and Innovations in 3D Printing Organs
Rothblatt is also focused on 3D printing technology to create artificial lungs, addressing the limitations of xenotransplantation for this delicate organ type. Her team is developing biopolymer lung models, utilizing a process that allows for high precision and the creation of complex structures mimicking natural lung anatomy. While there are skeptics regarding the viability of printed organs, Rothblatt remains determined, believing that manufacturing functional lungs is feasible and that her innovations could pave the way for organ transplantation. This pursuit of engineered organs highlights both the challenges faced and the relentless drive to find solutions in the realm of biotechnology.
At any given time, the US organ transplant waiting list is about 100,000 people long. Martine Rothblatt sees a day when an unlimited supply of transplantable organs—and 3D-printed ones—will be readily available, saving countless lives.
This story was written by senior biomedicine editor Antonio Regalado and narrated by Noa - newsoveraudio.com
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