The Stem Cell Podcast

Ep. 308: “Regeneration in the Cerebellum” Featuring Dr. Sumru Bayin

Nov 11, 2025
Dr. Sumru Bayin, a Group Leader at the Gurdon Institute, dives into the fascinating world of regeneration in the neonatal cerebellum. She discusses her groundbreaking research on Bergmann glia plasticity and how it impacts neuronal regeneration post-injury. Bayin also highlights the challenges in reactivating stem cell programs in adults and the innovative use of modified RNAs to improve neuronal proliferation while mitigating tumor risks. Her work, influenced by her training, emphasizes the potential for therapeutic advances in regenerative medicine.
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INSIGHT

Organoid Atlases Bridge Genotype To Phenotype

  • Large organoid atlases can link patient iPSC genotypes to distinct organoid phenotypes across NDD categories.
  • Such biobanks accelerate hypothesis generation despite phenotypic ambiguity in clinical labels.
INSIGHT

Developmental Timelines Are 'Mushy'

  • Human cortical development shows prolonged production of glutamatergic neurons into mid-gestation.
  • Developmental timelines are 'mushy' and less strictly deterministic than textbook lineage trees.
INSIGHT

Neonatal Plasticity Enables Regeneration

  • The neonatal cerebellum shows lineage plasticity after injury that adult brains largely lose.
  • Studying this window reveals how to harness endogenous neural stem cells for repair.
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