ICU Primary PrepCast #Epi 83 - ICU Primary Snippet 26 - Uteroplacental Circulation
Oct 27, 2023
Explore the specialized characteristics of uteroplacental circulation, including differences between maternal and fetal sides, oxygen levels in the fetus, and placenta functions. Dive into the dynamics of blood flow, oxygen exchange, and numerical values like PO2 and oxygen content. Discover how the placenta enhances oxygen transfer with Bor and Halide effects and fetal hemoglobin's superior affinity for oxygen.
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Uteroplacental Circulation Characteristics
- The fetus receives oxygenated blood from the mother with a PO2 of 100 and saturation of 98%.
- The uterine vein, draining the placenta, has a PO2 of 40 and saturation of 75%, similar to mixed venous blood.
Double Bohr and Haldane Effects
- The double Bohr effect facilitates oxygen transfer by increasing oxygen release in the acidic fetal environment and promoting oxygen uptake in the more alkalotic fetal circulation.
- The double Haldane effect enhances CO2 clearance from the fetus to the mother.
Visualizing Oxygen Transfer
- Draw oxyhemoglobin dissociation curves for both a normal adult and a fetus to understand oxygen transfer.
- Convert saturation to content to see how fetal hemoglobin's higher oxygen affinity aids in absorbing oxygen from maternal hemoglobin.