Patrick Holford: Simple Wisdom for a Healthy Life Anti-Age Your Brain Think Tank
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Jun 14, 2024 Dr Konrad Kowalski, analytical chemist who developed a dry blood spot glutathione test. Dr Filip Van Hulle, CoQ10 and mitochondrial specialist. Associate Professor David Vauzour, researcher on brain aging and antioxidants. They discuss glutathione measurement and decline, CoQ10/ubiquinol and statin interactions, dietary antioxidants and recycling, plus nutrition, supplements and mitochondrial support for brain aging.
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Brain Ageing Is Driven By Oxidation
- The brain ages mainly from oxidative stress because it uses disproportionate energy and generates many oxidants.
- Seven core antioxidants and a second line of B vitamins/minerals form a recycling defence network for brain ageing.
Why The Brain Is Especially Vulnerable
- The brain is uniquely vulnerable because it uses ~20% of body energy while being only ~2% of body weight.
- High lipid content (DHA) and limited regeneration amplify oxidative and mitochondrial damage during ageing.
Plaques, Tangles And Shrinkage Aren't Simple
- Amyloid plaques and tau tangles associate with ageing and Alzheimer's but their presence varies and doesn't map simply to normal ageing.
- Brain shrinkage arises from neuronal loss, synaptic decline and neuroinflammation, increasing with MCI and Alzheimer's.