Bach's St Matthew Passion was written in 1727 and was probably first performed as part of the Good Friday Service at Thomaskirche in Leipzig.
This programme explores ways in which Bach's St Mattew Passion touches and changes people's lives.
Guitarist Andrew Schulman describes what happened when he was played this music whilst he was in a coma. James Jacobs talks about the St Matthew Passion providing solace in difficult times during childhood.
And singer Emma Kirkby, conductor Paul Spicer and musical historian Simon Heighes explore how the music works and what it's like to perform.
Producer: Rosie Boulton.
First broadcast on BBC Radio 4 in 2012.