Gonna Be (500 Miles): Unleashing CRISPR’s Clinical and Diagnostic Potential

As CRISPR, the most groundbreaking biotech discovery of the 21st century, gained traction, Janice Chen, PhD, enrolled as a graduate student in the lab of Nobel laureate Jennifer Doudna, PhD, at UC Berkeley. In contrast to the many scientists around the world who sought to use CRISPR in animal models to make the long-awaited genome edits, Chen opted to transform CRISPR from a discovery in the lab into a tool that could save lives and improve health. To achieve this, Chen, Doudna, Trevor Martin, and Lucas Harrington were co-founders of Mammoth Biosciences, a pioneering CRISPR company.

Mammoth has persevered through the COVID-19 pandemic and the economic shifts in the biotech sector, mostly because of Chen's determination to broaden the scope of CRISPR and apply it to human diagnostics and health. This episode of Behind the Breakthroughs delves into that vision, revealing how Chen has played a critical role in the transformation of CRISPR from a mere concept in basic science to a miraculous medical breakthrough in the span of a decade.

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Hosted by Jonathan D. Grinstein

Audio mixed and mastered by David Mosely

Produced by Bill Levine

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