We are well aware of the normal, beneficial actions of oestrogens for both women and men, but what about negative actions? And is this a component of their normal biochemistry? Or are the negative actions more to do with aberrations in how we biotransform these vital hormones? Firstly, notice there's PLURAL when referring to oestrogens. They are not a single entity and the various oestrogens have multiple, even contradictory actions. Moreover, how does the body handle these powerful hormonal messengers once their job is done? Certainly, the evidence on oestrogen metabolism with relation to hormonally-driven cancers is far from unambiguous! Today, we speak with Beth Bundy, our regular guest on FX Medicine Podcast, to discuss just what's going on with oestrogens, what the evidence suggests may be going wrong with their metabolism, what this means for patients whose risk may be elevated, and how we can best help patients to minimise this risk. Listen in as Beth takes us into the tangled web of oestrogen metabolism and unravels some of the controversial research pointing to, and away from, oestrogen metabolites and cancer risk.