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ESC TV Today – Your Cardiovascular News

Season 2 - Episode 9: Management of cardiac amyloidosis - e-cigarettes and cardiovascular disease

Feb 15, 2024
This podcast covers topics such as management of cardiac amyloidosis, risks of e-cigarettes on cardiovascular health, and understanding treatment effects through hazard ratios and survival curves. It also discusses the durability of transcatheter-aortic valve procedures and prognostic markers in amyloid cardiomyopathy.
23:40

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Quick takeaways

  • Anticoagulation not superior to antiplatelet therapy in preventing recurrent stroke in patients with cryptogenic stroke and atrial cardiopathy.
  • Hemodynamic monitoring reduces heart failure hospitalizations and mortality but needs further optimization for clinical integration.

Deep dives

Preventing Recurrent Stroke in Cryptogenic Stroke and Atrial Cardiopathy Patients

In patients with cryptogenic stroke and atrial cardiopathy, the Arcadia trial found that anticoagulation was not superior to antiplatelet therapy for preventing recurrent stroke. Even after randomizing 1,015 participants to apixaban or low dose aspirin, the trial was stopped for futility since both groups showed similar annual rates of recurrent stroke. Post hoc analysis suggested that atherosclerosis, instead of a cardioembolic source, could be a significant factor in cryptogenic strokes.

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