
Nature Podcast Bowhead whales can live for more than 200 years – this protein might be why
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Oct 29, 2025 Vera Gorbanova, a researcher studying bowhead whale longevity, shares insights on how a protein called CIRBP enhances DNA repair, potentially explaining the whales' 200+ year lifespan. She reveals that this protein's abundance in whale cells could also benefit human health by improving DNA repair. Andreas Haugau-Lausten discusses breakthroughs in creating a universal antivenom using camelid nanobodies, addressing the global snakebite crisis. Their conversation explores how these scientific advances could transform aging research and venom treatment.
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Bowhead Longevity Defies Size-Based Cancer Risk
- Bowhead whales live over 200 years and maintain health despite large body size and many cells.
- Their longevity suggests enhanced DNA repair and other evolved mechanisms reduce cancer risk.
Superior Repair Of Double-Strand Breaks
- Bowhead fibroblasts show superior repair of DNA double-strand breaks compared with other species' cells.
- Enhanced double-strand break repair likely contributes to lower mutation rates, cancer resistance, and longevity.
CIRBP Is Massively Upregulated In Bowheads
- Proteomics highlighted cold-induced RNA-binding protein (CIRBP) at ~100× higher abundance in bowhead cells.
- High CIRBP levels stood out as a likely factor protecting and organizing repair at DNA breaks.
