Febrile

34: Febrile Digest - Enterococcus in IAI, Pharmageddon

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Mar 21, 2022
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ANECDOTE

Scott Crabtree's Training And Practice

  • Scott Crabtree described his training path: residency with the Air Force, a fellowship in New Hampshire, then returning to military service before settling at UC Davis.
  • He now practices clinical infectious diseases, stewardship, and infection prevention at UC Davis in Sacramento.
INSIGHT

Trials Show No Clear Benefit In Low-Risk IAI

  • Clinical trials generally show no clear benefit to empirically covering Enterococcus in low-risk community-acquired intra-abdominal infections.
  • Trial subanalyses are underpowered, so uncertainty remains when cultures later grow Enterococcus.
INSIGHT

Enterococcus May Be A Marker, Not The Cause

  • Observational studies suggest Enterococcus presence may associate with worse outcomes, but causality is unclear due to confounding variables.
  • Factors like location, source control, and patient comorbidities drive outcome differences more than organism identity alone.
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