Cost-effectiveness of ultra-low-dose quadruple combination therapy for high blood pressure

Combination Therapies for High Blood Pressure

Combination therapies for high blood pressure are rational and recommended by global guidelines, yet many patients still struggle to achieve blood pressure control. The Quartet trial demonstrated that a quad pill, consisting of four ultra-low dose blood pressure-lowering drugs in a single pill, was more effective in reducing systolic blood pressure than standard monotherapy. The study also conducted a cost-effectiveness analysis, which showed that the quad pill was cost-effective, with a cost per quality-adjusted life year well below the threshold for determining cost-effectiveness in Australia. The findings suggest that the quad pill strategy could improve outcomes in treating high blood pressure.