The Beyond Tomorrow Podcast with Julian Issa Top Longevity Scientist on Living 20 Years Longer & the Truth About Bryan Johnson – Matt Kaeberlein
What if we could add 20 healthy years to our lives—starting today?
In this episode of The Beyond Tomorrow Podcast, longevity pioneer Matt Kaeberlein, CEO of OptiSpan and host of the OptiSpan Podcast, joins me for a sweeping conversation on the science, skepticism, and promise of human lifespan extension.
From rapamycin and thymic regeneration to the XPRIZE and biological age tests, Matt shares deeply honest insights about what is real, what is hype, and what might actually work. You will learn why human connection could be the most overlooked longevity hack, what tests truly matter, and how to think like a scientist in the era of consumer health fads.
🎧 Expect to learn:
Why rapamycin remains the most promising anti-aging compound in animals
The truth about biological age tests, microbiome kits, and health influencers
Why Matt is cautiously optimistic about the longevity XPRIZE
The 4 pillars of health that matter more than any supplement
Why human connection is the most underrated predictor of joy and vitality
How Matt is experimenting with therapeutic plasma exchange and thymic rejuvenation
Why most startups chasing "longevity escape velocity" are missing the mark
📌 Plus: His surprisingly nuanced take on Bryan Johnson, and what Matt wants to do next in longevity.
Check out Matt's podcast: The Optispan Podcast with Matt Kaeberlein
🔔 Hit follow to stay ahead of the future of health.
🌍 Learn more: beyondtomorrowpodcast.com
📸 Instagram: @thebeyondtomorrowpodcast
⏱️ Timestamps:
0:00 – Intro
2:00 – Who Is Matt Kaeberlein & Why Longevity?
5:00 – Why Aging Is the #1 Health Problem
7:00 – Rapamycin: Hype, Hope & How It Might Work
10:00 – What Supplements Matt Actually Takes
13:00 – Plasma Exchange & Thymic Regeneration
17:00 – The Problem with Biohacking Culture
21:00 – Truth About Biological Age & Microbiome Tests
26:00 – Brian Johnson: What He’s Getting Right (and Wrong)
30:00 – Longevity Escape Velocity: Science or Sci-Fi?
34:00 – What the XPRIZE for Longevity Could Unlock
38:00 – Diagnostics That Actually Matter
42:00 – Why Human Connection Is the Ultimate Health Hack
45:00 – Hormones, DEXA, CGMs & Labs That Help
48:00 – What Matt Has Changed His Mind On
49:00 – What Brings Joy: The Real Point of Living Longer
50:00 – Final Thoughts & Where to Learn More
This podcast is for informational purposes only and is not medical advice