Elizaveta Semenova, a postdoctorate in Bayesian Machine Learning, discusses her work on Gaussian Processes for studying the spread of Malaria and fitting dose-response curves in pharmaceutical tests. She also talks about her latest paper on Bayesian neural networks for drug toxicity prediction and the interesting link between BNNs and Gaussian Processes.
01:02:12
forum Ask episode
web_stories AI Snips
view_agenda Chapters
auto_awesome Transcript
info_circle Episode notes
question_answer ANECDOTE
From Math to Epidemiology
Elizaveta Semenova initially pursued theoretical mathematics but found it too abstract.
She transitioned to epidemiology, driven by a passion for global health and a desire for more applied work.
insights INSIGHT
Bayesian First
Elizaveta Semenova's first exposure to statistical modeling was through Bayesian methods during her PhD.
She was later surprised to discover the prevalence of non-Bayesian approaches in the field.
volunteer_activism ADVICE
Slow but Exact
Prioritize slow but exact MCMC solutions over faster approximate methods when time isn't critical.
A better posterior distribution is worth the computational cost in many research contexts.
Get the Snipd Podcast app to discover more snips from this episode
I bet you heard a lot about epidemiological compartmental models such as SIR in the last few months? But what are they exactly? And why are they so useful for epidemiological modeling?
Elizaveta Semenova will tell you why in this episode, by walking us through the case study she recently wrote with the Stan team. She’ll also tell us how she used Gaussian Processes on spatio-temporal data, to study the spread of Malaria, or to fit dose-response curves in pharmaceutical tests.
And finally, she’ll tell us how she used Bayesian neural networks for drug toxicity prediction in her latest paper, and how Bayesian neural nets behave compared to classical neural nets. Ow, and you’ll also learn an interesting link between BNNs and Gaussian Processes…
I know: Liza works on _a lot_ of projects! But who is she? Well, she’s a postdoctorate in Bayesian Machine Learning at the pharmaceutical company AstraZeneca, in Cambridge, UK.
Elizaveta did her masters in theoretical mathematics in Moscow, Russia, and then worked in financial services as an actuary in various European countries. She then did a PhD in epidemiology at the University of Basel, Switzerland. This is where she got interested in health applications – be it epidemiology, global health or more small-scale biological questions. But she’ll tell you all that in the episode ;)
Our theme music is « Good Bayesian », by Baba Brinkman (feat MC Lars and Mega Ran). Check out his awesome work at https://bababrinkman.com/ !
Determining organ weight toxicity with Bayesian causal models: https://www.biorxiv.org/content/10.1101/754853v1
Material for Applied Machine Learning Days ("Embracing uncertainty"): https://github.com/elizavetasemenova/EmbracingUncertainty
Predicting Drug-Induced Liver Injury with Bayesian Machine Learning: https://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.9b00264
Ordered Logistic Regression in Stan, PyMC3 and Turing: https://medium.com/@liza_p_semenova/ordered-logistic-regression-and-probabilistic-programming-502d8235ad3f
Learning Bayesian Statistics