The Stem Cell Podcast

Ep. 300: “Autologous Cell Therapy” Featuring Dr. Jeanne Loring

Jul 22, 2025
Guest
Jeanne Loring
Dr. Jeanne Loring, Co-founder of Aspen Neuroscience and Professor Emeritus at Scripps Research, shares fascinating insights from her work on autologous cell therapies. She discusses innovative methods for generating gametes from the endangered northern white rhinoceros and the recent successes in Parkinson's disease trials. Loring unveils her project sending stem cells into space, exploring microgravity's effects on neuroscience. She emphasizes the vital need for genetic diversity in iPSC lines and the ethical considerations in stem cell research.
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INSIGHT

Reevaluating Transitional Cerebellar Progenitors

  • Single-cell RNA seq data can reveal artifacts like ambient RNA that mislead interpretation of novel cell types.
  • Reanalysis of data prevented false conclusions about a transitional cerebellar progenitor cell type.
INSIGHT

Co-Differentiation Enables Vascularized Organoids

  • Vascularization in organoids needs simultaneous co-differentiation of mesoderm and endoderm for organ-specific vascular structures.
  • This integrated developmental approach surpasses assembloids by growing tissues together, mimicking embryonic processes.
INSIGHT

Engineering Functional Liver Vasculature

  • Creating tissue-specific sinusoidal vessels in liver organoids requires engineering approaches that enable self-organization and functional perfusion.
  • Fully perfusable vascular networks in organoids enable correction of disease phenotypes such as hemophilia in vivo.
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