GasGasGas - The FRCA Primary Exam Podcast VivaCast 010 - Physiology - Classifying Hypoxia, Oxygen Delivery and Oxy-Haemoglobin Sat Curves
Feb 28, 2025
Dive into the fascinating world of hypoxia as the hosts dissect its classifications, including hypoxic, anemic, histotoxic, and ischemic types. Discover how oxygen is delivered to tissues and the intricate interplay of hemoglobin with factors like 2,3-DPG and pH. Learn why oxygen delivery is crucial for cellular respiration and how it shifts depending on conditions. The discussion wraps up with insights on the oxyhemoglobin dissociation curve and what impacts hemoglobin's affinity for oxygen. Educational and engaging!
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Four Ways Oxygen Fails To Reach Cells
- Hypoxia is best understood as failure to deliver oxygen from atmosphere to mitochondria in four main ways.
- Classifications: hypoxic, anemic, stagnant (ischemic), and cytotoxic (histotoxic).
Oxygen Delivery = Flow × Content
- Oxygen delivery (DO2) combines cardiac output and blood oxygen content into one value representing tissue supply.
- Remember the key constant: 1.34 mL O2 carried per gram of haemoglobin for calculations.
Use Local Factors To Predict O2 Offloading
- Use local metabolic factors to predict O2 offloading at the capillary level during clinical reasoning.
- Consider pH, 2,3-DPG, CO2 and temperature when assessing oxygen release to tissues.