Gut Health and Resilience - Dr. Chris Lowry, Part 1 - Ep. 48
Sep 19, 2023
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Dr. Chris Lowry discusses microbiome-gut-brain axis, how gut health impacts mental health, and potential interventions for anxiety disorders. Topics include gut microbiome diversity through diet, probiotics for gut health recovery, and communication pathways between gut and brain.
Consuming a variety of plants promotes gut health and increases microbial diversity.
Antibiotics impact gut microbiome diversity, emphasizing the importance of recovery through a diverse diet.
Deep dives
Understanding the Gut Microbiome
The gut microbiome plays a vital role in human health, being a complex ecosystem comprising bacteria, archaea, fungi, viruses, and other microorganisms. A diverse gut microbiome is essential for overall health, with high diversity indicating a healthier microbiome. Consuming a variety of plants, including fresh fruits, vegetables, nuts, seeds, and fermented foods, promotes gut health and increases microbial diversity. Studies have shown a direct correlation between plant diversity in the diet and gut microbiome richness, highlighting the importance of dietary choices in maintaining a healthy gut microbiome.
Effects of Antibiotics on the Gut Microbiome
Antibiotics have a significant impact on the gut microbiome, leading to a decrease in microbial diversity. Prolonged or multiple antibiotic courses can severely disrupt the gut microbiome, making individuals susceptible to conditions like C. diff infection. Recovery of the gut microbiome after antibiotic treatment is crucial and can be aided by adopting a diet rich in fish, vegetables, fruits, fermented foods, and diverse plant-based foods to support microbial diversity and reestablish a healthy gut environment.
Probiotics and Gut Health
Probiotics, while beneficial, should be chosen carefully based on strain specificity and clinical evidence of efficacy for specific health conditions. The Physician's Guide to Probiotics provides valuable information on probiotic strains, brand names, formulations, and clinical evidence to guide the selection of probiotic supplements. Consuming a diverse range of probiotics and synbiotics, along with maintaining a healthy lifestyle and dietary habits, can contribute to promoting gut health and microbial diversity.
Nutritional Factors Affecting Gut Microbiome Diversity
There are various diet and lifestyle factors that influence gut microbiome diversity. Foods like fish, vegetables, fruits, fermented foods, beans, shellfish, and whole grains have been associated with increased microbial diversity and gut health. Conversely, processed meats, dairy products, sugary drinks, and diet soft drinks have been linked to reduced gut microbiome diversity, highlighting the importance of dietary choices in maintaining a balanced and diverse gut microbiome.
Christopher A. Lowry, Ph.D., is an Associate Professor at the University of Colorado Boulder in the Departments of Integrative Physiology, Psychology, and Neuroscience, the Center for Neuroscience, and the Center for Microbial Exploration.
He has additional appointments in the Department of Physical Medicine and Rehabilitation and the Center for Neuroscience at the University of Colorado Anschutz Medical Campus, as a Principal Investigator in the Department of Veterans Affairs Eastern Colorado Health Care System, VA Rocky Mountain Mental Illness Research, Education, & Clinical Center, and as the director of the Behavioral Neuroendocrinology Laboratory at CU Boulder.
He is also the Co-Founder and Co-Director of the Military and Veteran Microbiome Consortium for Research and Education.
Dr. Lowry’s research program at CU Boulder focuses on understanding stress-related physiology and behavior, emphasizing the microbiome-gut-brain axis. His research is designed to lead to novel, microbiome-based interventions for preventing anxiety, mood, and trauma- and stressor-related disorders, such as posttraumatic stress disorder (PTSD).
In this episode, we talk with Dr. Lowry about his work involving the microbiome-gut-brain axis, a research term for how our digestive systems' health is intertwined with our brains' health. We’ll cover broad theoretical topics like what the gut microbiome is and how it works, to the practical side of things like what you can eat to make it healthier.
We’ll also discuss some of Chris’ work on how the gut biome can affect our resilience and susceptibility to traumatic brain injury and post-traumatic stress, as well as his research in these areas, specifically involving the veteran and first responder communities.
More about Dr. Lowry: https://www.colorado.edu/iphy/people/faculty/christopher-lowry
Timestamps:
00:00:22 Who is Dr. Chris Lowry
00:03:08 Background, Education and the Microbiome
00:10:28 Where is the Biome
00:13:02 What Benefits Our Microbiome
00:16:46 How Does Food Diversity Affect the Microbiome
00:20:15 Blood/Gut Barrier
00:22:28 Fiber: Diversity is Best
00:27:05 How do Antibiotics Affect the Microbiome
00:29:13 Recovery From Antibiotics
00:30:31 Guidelines in Probiotic Diversity
00:35:00 Outro
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