Aubrey Marcus Podcast
Groundbreaking DMT research w/ Jon Dean and John Chavez #312
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Quick takeaways
- DMT is found endogenously in the mammalian brain, sparking a renaissance in psychedelic research.
- MAO inhibitors may modulate the effects of DMT, shedding light on their combined interaction.
- DMT shows potential in treating mental health conditions like depression, with mood-improving effects noted.
- Linking DMT levels to the Wim Hof Method offers promise for addressing neurodegenerative diseases like Alzheimer's.
Deep dives
D M T: The Endogenous Molecule?
Exploring the role of DMT as a potential endogenous molecule in the brain, discussions revolve around its spiritual and hallucinogenic properties. Scientific research, exemplified by John Dene and John Chavez, aims to unravel the mysteries of DMT's origin, function, and impact on consciousness. Studies suggest DMT's presence in rat brains comparable to serotonin levels, hinting at potential neurotransmitter-like roles.
Role of M A O Inhibitors and DMT Interaction
Delving into the impact of MAO inhibitors on DMT availability, the conversation extends to how these inhibitors may modulate the effects of DMT in the brain. Speculations arise on the potential cascade effect of modulating MAO activity in conjunction with DMT presence, shedding light on their combined interaction within the brain.
Implications of DMT in Mental Health and Neurotransmission
The podcast explores the potential implications of DMT in mental health conditions such as depression and anxiety. Studies indicate mood-improving effects of sub-psychotropic doses of DMT in rats, hinting at its role in mood regulation, akin to traditional neurotransmitters like serotonin. The discussion touches on how stress can influence endogenous DMT levels and its relevance in mood disorders.
DMT, Wim Hof Method, and Neurogenerative Diseases
An upcoming study linking DMT levels to the Wim Hof Method holds promise for addressing neurogenerative diseases like Alzheimer's. By correlating the anti-inflammatory and immune benefits of DMT with controlled hypoxia induced by the Wim Hof Method, a potential therapy for conditions like Alzheimer's is explored. The study seeks to uncover the therapeutic potentials of DMT and controlled hypoxia in neurodegenerative disorders.
The Influence of Psychedelics on Brain Activity
Psychedelics like DMT are believed to increase brain entropy, leading to more communication between different brain regions. Studies have shown that psychedelics can elevate brain entropy levels higher than during waking or REM sleep. This increased entropy is associated with altered states of consciousness and enhanced communication among various brain areas.
Exploring the Brain's Default Mode Network
Aldous Huxley's theory suggests that psychedelics open the brain to more information by reducing the default mode network's activity. By restricting blood flow to this network, the brain can access different dimensional realities and receive enhanced information. Psychodelics like ayahuasca have been shown to influence the default mode network, facilitating a broader range of brain communication.
Evaluating the Relationship Between Psychedelics, Meditation, and Mind Modulation
Experienced meditators show similarities in brain activity changes with psychedelic administration, indicating overlaps between meditative and psychedelic states. Meditation can down-regulate executive brain areas while enhancing sensory regions. This connection suggests a potential shift in consciousness and perception for individuals engaging in deep meditative practices or using psychedelics.
In this podcast I am joined by one of the very few people on earth who has scientifically studied DMT, Dr. Jon Dean, and John Chavez, founder of DMT Quest. We talk about the research that has been conducted over this mystical and controversial compound, and the potential implications of such findings. Jon recently published a study that has ended the debate on whether or not DMT is produced endogenously in the mammalian brain. It is. We’ve entered a renaissance of psychedelic study; this is just the beginning and it’s going to take a concerted effort to fund, support, and advocate for the proliferation of this research. Check out the DMT Quest documentary | https://bit.ly/3ce3Cdz
This episode is sponsored by:
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