VJHemOnc Podcast cover image

VJHemOnc Podcast

Addressing unmet needs in myeloma: early detection, frail/elderly patients, triple-class exposed disease, & more!

Mar 14, 2025
In this enlightening discussion, Joseph Mikhael, a myeloma expert from TGen and the International Myeloma Foundation, tackles the pressing issues in myeloma treatment. He highlights breakthroughs in managing smoldering myeloma and the unique challenges faced by frail and elderly patients. The conversation also dives into innovative therapies for triple-class refractory disease, and the critical examination of racial disparities in myeloma care. Mikhael’s insights showcase the need for improved access and personalized treatment approaches.
27:48

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Early intervention in smoldering myeloma necessitates robust risk stratification and clinical trials to validate survival benefits before altering treatment protocols.
  • Addressing racial disparities in myeloma care requires systemic change to enhance access to treatment and improve outcomes for underrepresented populations.

Deep dives

Early Intervention in Smoldering Myeloma

Early intervention for smoldering myeloma raises significant considerations for healthcare professionals, particularly regarding risk stratification and treatment recommendations. Research indicates that approximately 10% of patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) may develop smoldering myeloma, affecting a substantial population in the UK. It is crucial to categorize smoldering myeloma into low, standard, and high-risk groups, as higher-risk patients demonstrate a 60-80% chance of progressing to active myeloma within two years. While researchers are exploring intervention strategies, the necessity for clinical trials showcasing overall survival advantages and acceptable toxicity profiles remains paramount before changing current practice norms.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode