The Geography of Autoimmunity, Part 2

This episode delves into what we can learn about the impact of the environment on autoimmunity, digging into how rates of autoimmunity can vary drastically in different parts of the world.

·       Intro 0:12

·       In this episode 0:16

·       Dr. Brian Greenwood 0:22

·       The geography of autoimmunity 7:01

·       Type 1 diabetes 10:31

·       Finland and type 1 diabetes 13:57

·       Socioeconomics 17:59

·       Genetics and autoimmune diseases 24:19

·       Migration studies 24:53

·       Denmark and multiple sclerosis 30:06

·       Coming up in part 3 36:02

·       Thanks for listening 38:16

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Bach JF. N Engl J Med. 2002;doi:10.1056/NEJMra020100.

Bodansky HJ, et al. BMJ. 1992;doi:10.1136/bmj.304.6833.1020.

Dean G, et al. J Neurol Neurosurg Psychiatry. 1997;doi:10.1136/jnnp.63.5.565.

Hammond SR, et al. Brain. 2000;doi:10.1093/brain/123.5.968.

Hawkes CH, et al. Mult Scler Relat Disord. 2019;doi:10.1016/j.msard.2019.08.001.

Karvonen M, et al. Diabetes Care. 1999;doi:10.2337/diacare.22.7.1066.

Kondrashova A, et al. Diabetes Care. 2007;doi:10.2337/dc06-0711.

Marciulionyte D, et al. Diabetologia. 2001;doi:10.1007/s001250051574.

Nielsen NM, et al. Brain. 2019;doi:10.1093/brain/awz088.

Patterson CC, et al. Diabetologia. 2012;doi:10.1007/s00125-012-2571-8.

Sandy JL, et al. Pediatr Diabetes. 2021;doi:10.1111/pedi.13191.