Aubrey de Grey, PhD, is a biomedical gerontologist and Chairman and Chief Science Officer of The Methuselah Foundation. His major research interests are the role and etiology of all forms of cellular and molecular damage in mammalian aging, and the design of interventions to reverse the age-related accumulation of such damage. He has published extensively on these and other areas of gerontology, and is also Editor-in-Chief of Rejuvenation Research, the only peer-reviewed academic journal focusing on intervention in aging. He is the organiser of an ongoing series of conferences and workshops that focus on the key biomedical research relevant to SENS, and he also oversees the Methuselah Foundation's growing sponsorship of SENS research worldwide.In this conversation with D.J. Grothe, Aubrey de Grey explains aging, and the SENS (Strategies for Engineered Negligible Senescence) program that seeks to reverse aging in our lifetime. He explains how his work is, and is not, continuous with "transhumanism." He addresses challenges the medical and scientific establishment have brought against his work, and how his project is different than the quackery so widespread in the anti-aging movement. He also discusses some of the social and existential problems that ending aging may create for our civilization.