Short Wave

How Long Does COVID Immunity Last Anyway?

Sep 21, 2021
Michaeleen Doucleff, an NPR science correspondent specializing in COVID immunity, dives into the complexities of vaccine protection. She discusses how immunity from COVID vaccinations varies over time, focusing on the dynamics of antibody responses and the exciting role of T-cells. Doucleff also explores the synergy of natural infection and vaccination, showing how they enhance immunological defenses. With insights on resilience against variants, she paints a hopeful picture of how our bodies adapt to this evolving virus.
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INSIGHT

Antibody Potency Increase

  • Antibody levels decrease after vaccination, but the remaining antibodies become more potent.
  • These antibodies are better at neutralizing the virus, requiring fewer to offer protection.
INSIGHT

Antibody Durability and Flexibility

  • Antibodies become more durable and flexible after vaccination.
  • They can last for decades, potentially a lifetime, offering long-term protection.
INSIGHT

Breakthrough Infections and Immunity

  • Breakthrough infections can occur in vaccinated individuals due to waning antibody levels.
  • However, existing immunity, including T-cells, helps prevent severe disease.
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