Veneprasan and Fezilinitant offer new treatment options for severe GERD and menopausal symptoms respectively.
Cannabis use has both benefits for sleep regulation and risks of adverse cardiovascular effects, emphasizing careful consideration.
Revised daily step count recommendations challenge the conventional 10,000 steps, suggesting health benefits with fewer steps per day.
Deep dives
Update on Novel Medications: GERD Treatment and Menopausal Symptoms
One of the recent FDA-approved medications discussed in the podcast was Veneprasan, a potassium competitive acid blocker used for refractory GERD. It showed efficacy in severe erosive esophagitis. Another medication, Fezilinitant, a neurokinin receptor blocker, was highlighted for menopausal symptom treatment due to its effectiveness in reducing hot flashes. The session also covered RSV vaccines, with Moderna developing an mRNA vaccine. The fourth FDA-approved drug, Jeparone, a 5-HT1A partial agonist, offers a potential alternative for depression treatment without weight gain or sexual side effects.
Pearls on Cannabis Use and Health Implications
In the discussion on cannabis during the addiction medicine update, observational data revealed that cannabis has sympathomimetic properties impacting the cardiovascular system. While some use cannabis for pleasure and sleep regulation, concerns such as rebound insomnia and cannabis hyperemesis syndrome were also addressed. The session emphasized recognizing both the benefits and risks associated with cannabis use.
Insights on Step Count Recommendations and Health Implications
Contrary to the commonly known 10,000 step recommendation, recent studies, including the stevens at all study in the Journal of American College of Cardiology, suggested that as few as 2,517 steps per day could reduce all-cause mortality. The optimal daily step count for significant health benefits was found to be around 8,763 steps. This information offers a revised perspective on the importance of daily step counts for health outcomes.
Cannabis Use and Elective Surgery
Preoperative cannabis use is linked to a significant increase in adverse cardiac outcomes before surgery, emphasizing the importance of advising patients to reduce cannabis consumption prior to elective procedures. While cannabis use may elevate risks for heart-related conditions like myocardial infarction and stroke, the impact is notably less severe than tobacco smoking. This information underscores the need for thorough patient counseling and awareness of the cardiovascular effects of cannabis, particularly given its rising use among the elderly population.
Interstitial Lung Disease (ILD) Overview
The podcast delves into the complexities of diagnosing and managing interstitial lung disease (ILD), highlighting the challenges in distinguishing between acute ILD causes and the varying approaches to diagnostic testing and treatment. With bronchoscopy as a primary diagnostic tool, the debate within pulmonology circles revolves around balancing aggressive testing with timely intervention for ILD patients. The discussion emphasizes the significance of cautious treatment strategies, such as a standardized 40-milligram prednisone regimen, alongside the recognition of potential risks, including renal crisis in certain ILD subtypes.
We cover angina, COPD-asthma overlap, home oxygen, colon cancer screening, cancer survivorship, tobacco cessation, e-cigarettes, step counts for health, new drugs, the RSV vaccine, addiction medicine, interstitial lung disease, APOL1-mediated kidney disease, testosterone therapy, antimicrobial resistance, office-based allergy testing and more! The Curbsiders review highlights, clinical pearls, and practice-changing updates from the American College of Physician Internal Medicine Meeting #IM2024!
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