Dr. Martin Kneyber is Chief of the Division of Paediatric Critical Care Medicine at the Beatrix Children’s Hospital, University Medical Center the Netherlands. He is interested in better understanding the respiratory pathophysiology in mechanically ventilated children. His basic science research focuses on ventilator-induced lung injury and its relationship with multiple system organ failure, he is also a principal investigator for PROSpect–Prone and Oscillation pediatric clinical trial.

Learning Objectives:

By the end of this podcast, listeners should be able to discuss:

The physiologic rationale supporting the use of high frequency oscillatory ventilation (HFOV).
Patient populations most likely to benefit from HFOV.
Key published evidence that informs our use of HFOV in pediatric critical care.
An expert approach to managing a patient with HFOV.
Next steps in research that will direct our understanding of the use of HFOV in pediatric critical care.

References:

Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med. 2013 Feb 28;368(9):795-805. doi: 10.1056/NEJMoa1215554. Epub 2013 Jan 22. PMID: 23339639.

de Jager P, Curley MAQ, Cheifetz IM, Kneyber MCJ. Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease. Pediatr Crit Care Med. 2023 Jun 1;24(6):e272-e281. doi: 10.1097/PCC.0000000000003211. Epub 2023 Mar 6. PMID: 36877029; PMCID: PMC10226461.

https://prospect-network.org/

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Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

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