Epigenetics to Tendonitis: Exploring Emerging Health Research and Treatment Options

Broadcast from KSQD, Santa Cruz on 5-08-2025:

• Dr. Dawn examines groundbreaking research on rising rates of early-onset colorectal cancer worldwide, explaining how researchers have identified a bacterial toxin called colibactin produced by specific E. coli strains that appears to cause early genetic mutations in cancer-controlling genes, potentially explaining why younger generations face significantly higher cancer risks. She discusses how modern medical practices like antibiotic overuse and cesarean deliveries may disrupt protective gut microbiomes, while diets low in fiber and high in animal fats create conditions where harmful bacteria thrive and damage the protective mucosal barrier, potentially exposing colon cells to cancer-causing mutations.
• Dr. Dawn explains fascinating research on transgenerational memory in C. elegans worms and mice, where learned aversions to specific odors are genetically passed down to offspring through epigenetic mechanisms involving methylation and RNA pathways, challenging traditional views on inheritance and suggesting implications for human genetics.
• Responding to an email about posterior tibial tendon disease (PTTD), she offers comprehensive management strategies including cross-massage with ice, proper footwear selection, careful stretching techniques, and anti-inflammatory approaches while cautioning against invasive procedures like steroid injections that might weaken tendons.
• She discusses promising research on rosemary's potential in Alzheimer's treatment, explaining how carnosic acid activates the NRF2 pathway that controls antioxidant proteins, with researchers developing a more stable chemical analog that reduced inflammation and improved memory in mouse models of Alzheimer's disease.
• Dr. Dawn provides updates on vaccination recommendations, noting that egg allergy questions are no longer needed before flu vaccines, pneumococcal vaccines are now recommended for all adults over 50, and explaining the small risk of Guillain-Barré syndrome with RSV vaccines compared to the much larger risk of RSV-related deaths.
• She shares information about a new hypertension risk calculator called PREVENT that reclassifies many patients to lower risk categories, potentially allowing 2.6 million Americans to manage their blood pressure through lifestyle changes rather than medication, particularly benefiting older women who face different risk profiles than men.