Core EM - Emergency Medicine Podcast

Episode 135.0 – Occult Causes of Non-Response to Vasopressors

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Mar 5, 2018
Explore the intriguing challenges of treating hypotensive patients who don’t respond to vasopressors. The discussion dives into vital pathologic factors like metabolic acidosis and myxedema coma. Understand the critical role of swift interventions and the significance of comprehensive patient reassessments. Anaphylaxis management also takes center stage, emphasizing epinephrine's importance and the latest steroid research in critical care. Discover how hypocalcemia can complicate treatment and why rapid ultrasound evaluations are crucial.
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ADVICE

Pause Before Increasing Vasopressors

  • Prioritize treating the underlying cause of shock over just increasing vasopressor doses.
  • Take a cognitive pause to reconsider diagnosis if high dose pressors do not improve hypotension.
ADVICE

Check and Treat Acidosis

  • Check for metabolic acidosis in shock patients not responding to pressors using blood gas and metabolic panel.
  • Treat the underlying cause; bicarbonate usually not helpful long term but may bridge to dialysis.
ADVICE

Recognize and Treat Hypothyroidism

  • Consider severe hypothyroidism or myxedema coma in refractory shock, especially if physical signs align.
  • Empirically treat with levothyroxine without waiting for labs if suspicion is high.
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