"The Friendly Physician" (April 7, 1966)

Sure, Gilligan's Island may have skewed family-friendly, but its love of genre parody meant that it did a body swap episode in which all of its female characters end up in male bodies. Horny! That's enough to get our attention, even without the mad scientist bad guy with perversely vampiric sexual energy.

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Gilligan's Island Does a Body Swap Episode