Eagle's Eye View: Your Weekly CV Update From ACC.org Frailty Status and Mortality Risk in PCI; Delays in Treatment in STEMI; Arterial Events with Genetic-based Vascular Disease
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Jun 25, 2025 This episode dives into frailty status and its alarming link to increased mortality during percutaneous coronary intervention. Delays in treating STEMI patients are explored, revealing how timing can significantly impact recovery. The discussion also sheds light on genetic factors influencing arterial events in conditions like heritable thoracic aortic disease and Loeys-Dietz Syndrome. These insights highlight the importance of swift treatment and genetic awareness in managing cardiovascular health.
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Frailty's Impact on PCI Mortality
- Frailty status significantly increases mortality risk after PCI, with severely frail patients showing over 20% mortality compared to 0.5% in non-frail.
- Frailty adds predictive value beyond traditional clinical risk scores and should be assessed systematically before coronary interventions.
Use Frailty in PCI Decisions
- Incorporate frailty assessment systematically into risk evaluation for patients undergoing PCI.
- Discuss frailty risks openly with patients and families to guide informed decisions about coronary interventions.
STEMI Delays Raise Mortality Risk
- Despite knowledge that timely STEMI intervention lowers mortality, many hospitals fail to meet recommended door-to-device times.
- Delays double in-hospital mortality risk, indicating urgent need to improve STEMI treatment workflows nationwide.