Evolving Psychiatry What IS Depression? | Daniel Nettle | Evolving Psychiatry Podcast #52
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Oct 28, 2025 
In this engaging discussion, Daniel Nettle, a behavioral scientist and professor renowned for his research on depression and public health, tackles the multifaceted nature of depression. He dives into the interplay of biology, psychology, and societal factors, exploring how different explanations shape stigma and treatment. Nettle argues for the importance of evolutionary and ecological perspectives, highlighting how modern stressors can exacerbate depression. He also critiques simplistic 'broken brain' metaphors and emphasizes addressing environmental needs to foster mental well-being.
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Evolutionary Explanations Aren't Genetic Determinism
- Evolutionary explanations do not imply a single 'gene for depression'.
- Nettle frames evolution as mechanisms shaped to respond to environments, not deterministic destiny.
Depression Spans Biology, Psychology And Social Meaning
- Depression sits at the intersection of biology, psychology and social construction.
- Diagnostic criteria and social norms shape what we call 'depression' over time.
Prefer An Ecological Frame Over Gene Talk
- Use 'ecological' to stress environment-driven mechanisms rather than genes.
- Focus on environmental factors like resource shortage, isolation and unpredictability that trigger mood responses.
