The Internet Book of Critical Care Podcast
IBCC EP 60 - Methemoglobinemia
Oct 15, 2019
This episode explores methemoglobinemia, a condition where hemoglobin is oxidized, causing severe symptoms such as seizures and arrhythmia. It discusses the diagnostic approach, methods of measuring methemoglobin levels, and treatment options including the use of methylene blue. It also covers the treatment of dapsone-induced methemoglobinemia and potential complications.
18:07
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Quick takeaways
- Methemoglobinemia can be caused by various substances including medications, street drugs, and chemical exposures.
- Diagnosis of methemoglobinemia is based on clinical presentation and can be confirmed through methemoglobin level measurement and color chart.
Deep dives
Physiology of oxidizing hemoglobin and its implications
Normally, hemoglobin is in its reduced state (Fe2+). However, when other substances oxidize it to the ferric state (Fe3+), it can no longer transport oxygen or pick up carbon dioxide in the tissues. This poses a major problem and can lead to various symptoms.
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