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Immune Related Adverse Events of Checkpoint Inhibitors
Mar 26, 2024
Dr. Laura Cappelli discusses Immune Related Adverse Events (IRAEs) of checkpoint inhibitors. She explains their development, common occurrences, risk factors, and the importance of a multidisciplinary approach. Topics include monitoring strategies, treatment approaches, collaboration between rheumatology and oncology, and using corticosteroids as primary therapy.
53:22
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Quick takeaways
- Immune checkpoint inhibitors can lead to immune-related adverse events like inflammatory arthritis, demanding careful monitoring and treatment.
- Multidisciplinary approach with oncologists and rheumatologists is essential for managing immune-related adverse events effectively.
Deep dives
Understanding Cancer Immunotherapy and Immune-Related Adverse Events
Cancer immunotherapy has transformed oncology by enhancing outcomes in previously challenging cancers. These treatments unleash the immune system to combat cancer, leading to immune-related adverse events (IRAEs) that can mimic rheumatic diseases. Dr. Laura Capelli highlights the complexity of IRAEs, including their occurrence, common types like inflammatory arthritis and methods for monitoring and treating them using D-Mards and Biologics.
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